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Biological Models in Radiopharmaceutical Development
This book discusses how biological models are used in the development of radiopharmaceuticals—compounds labelled with radionuclides that are used for imaging or treating diseases. It covers how to design candidate radiopharmaceuticals, choose appropriate biological models (animal species, transgenic models, in vitro vs in vivo), and how tomographic physiological chemistry (PET, SPET etc.) plays a role in evaluating these compounds. It also addresses species differences, choice of radionuclide, ethical considerations in animal models, and practical aspects of screening and preclinical testing.
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