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Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets
The book gives an accessible introduction to molecular mechanisms by which toxic chemicals damage cells and tissues. It links molecular or biochemical events (e.g. altered signal transduction, generation of reactive metabolites, oxidative stress, disruption of mitochondria, interference with calcium homeostasis, etc.) to physiological or histological toxic outcomes. It’s richly illustrated, has review questions, and is aimed at advanced undergraduates / graduate students in toxicology, pharmacology, environmental science, etc. The second edition updates and expands on the first, adding new material on mitochondrial dysfunction, signal transduction disruption, systems toxicology, etc.
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