BOOK
Organic Reactions, Volume 47
Organic Reactions, Volume 47 provides a comprehensive and critical review of two advanced synthetic methodologies in organic chemistry. The first chapter focuses on lateral lithiation reactions promoted by heteroatomic substituents, exploring the mechanisms, scope, and selectivity imparted by oxygen, nitrogen, and other heteroatoms in aromatic and heteroaromatic lithiation processes. It discusses how these substituents direct site-selective deprotonation, enabling regioselective functionalization and strategic building of complex molecular architectures.
The second chapter examines the intramolecular Michael reaction, a powerful synthetic tool for the construction of rings and complex frameworks. It reviews the mechanistic aspects of intramolecular conjugate additions, stereochemical outcomes, and synthetic applications, supported by numerous examples from the literature and detailed experimental procedures.
As with all volumes in the Organic Reactions series, the book emphasizes practical laboratory details, including scope, limitations, experimental conditions, and representative examples, making it a trusted reference for organic chemists engaged in research and development.
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