BOOK
The Logic of Chemical Synthesis
The Logic of Chemical Synthesis by Elias J. Corey and Xue-Min Cheng presents a systematic approach to solving complex organic synthesis problems through retrosynthetic analysis. The book is structured into three parts:
General Approaches to the Analysis of Complex Synthetic Problems: This section introduces the fundamentals of retrosynthetic analysis, emphasizing the logical reduction of molecular complexity to generate possible synthetic pathways. It discusses various strategies, including transform-based, structure-based, topological, stereochemical, and functional group-based approaches, highlighting the concurrent use of multiple independent strategies to guide problem-solving.Specific Pathways for the Synthesis of Complex Molecules: Part two provides a collection of multistep syntheses, offering integrated information on synthetic methods and pathways for constructing complex target molecules. These examples illustrate the application of the principles discussed in the first part, focusing on the reactions of synthesis and specific examples of retro synthetically planned syntheses. Guide to the Original Literature of Multistep Synthesis: The final section serves as a comprehensive guide to the extensive literature on multistep synthesis, including information on more than six hundred interesting multistep syntheses of biologically derived molecules. This compilation aims to serve as a convenient reference for chemists seeking insights into the structural range and variety of target molecules.
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